Hi-Tech Estrogenex® 90 Tablets
ESTROGENEX is a nutritional
supplement, available without a prescription, designed to normalize all hormone
levels, yielding a wide spectrum of health and anti-aging benefits.
ESTROGENEX is a multi-pathway formulation that minimizes or eliminates
the undesirable effects associated with an estrogen dominant environment.
ESTROGENEX maintains the correct testosterone to estrogen ratios that yield
the benefits associated with normal estrogen levels. ESTROGENEX acts as
an irreversible anti-aromatase agent and is thus a powerful elevator of total
testosterone and maximum liberator of free testosterone. ESTROGENEX may
also play a role in long-term selective estrogen blocking and/or inhibition of
selective estrogen signaling. ESTROGENEX may contribute to notable
improvements in muscular growth and fat loss, in addition to its wide array of
health and anti-aging benefits.
ESTROGENEX is designed for:
- Normalization of all hormone levels, with specific tendencies toward
testosterone dominance, in all aging males.
- Prevention and reversal of Gynecomastia.
- Adjunctive supplementation for men undergoing hormone replacement
therapy to ensure that raising testosterone levels will not yield an
undesirable increase in estrogen levels.
- A natural, more effective alternative for traditional testosterone
hormone replacement therapy.
- Bodybuilders and athletes during and immediately after periods of
anabolic steroid use for the purpose of stimulating endogenous testosterone
production.
Testosterone: Free-Testosterone and Plasma Protein-Bound Testosterone
Testosterone exists in the blood in either an active (free) or unbound state
(+-2%) or inactive state bound to one of two proteins:
sex-hormone-binding-globulin (SHBG) (+-45%) or albumin (+-53%). Only when
testosterone is in its free state can it directly interact with cellular
receptors and exert its activity. SHBG preferentially binds to testosterone over
estrogen. Higher levels of SHBG in women help to maintain higher estrogen to
testosterone ratios. Increased estrogen leads to an increase in SHBG. Thus,
lowering the level of SHBG allows for an increased level of free testosterone.
Obviously, if testosterone finds it more difficult to locate available plasma
proteins in the presence of the additional compound, more will be left in an
unbound state.
The amount of free testosterone can be altered (increased) by the use of
aromatase inhibitors (the less testosterone that is synthesized [aromatized]
into estrogen, the more total testosterone) or inhibitors of the plasma proteins
that bind into testosterone. Manipulating the tendency of a testosterone to
exist in an unbound state is an effective way to alter the overall activity and
potency of one's overall testosterone levels. Higher levels of testosterone
produce an enhanced anti-glucocorticoid effect, which yields an anti-catabolic,
or more precisely, anti-proteoolytic, effect on muscle cells. This indirect
anabolic effect is the result of testosterone's high affinity for binding with
glucocorticoid receptors, thus blocking the normal messenger pathway that
triggers protein release from muscle tissue. More free testosterone also likely
results in higher concentrations of IGF-1 and IGF-1 receptor sites in skeletal
muscle tissue. Correspondingly, lower testosterone also likely yields less IGF-1
production and a corresponding decrease in IGF-1 receptor sites. Lower free
testosterone also likely means a weaker immune system.
The Synthesis (Aromatization) of Testosterone to Estrogen in Males and the
Significance of Maintaining Correct Testosterone to Estrogen Ratios
Although testosterone is considered to be a male hormone and estrogen a female
hormone, both hormones exist in both males and females and serve important
functions for both. Estrogen is a term that really represents a collection of
female hormones, with esterone predominating. Since esterone is the estrogen
that is normally in the highest concentration, it is an excellent marker for
basic estrogen levels for that reason. At least three estrogens have multiple
and overlapping functions. Men obtain their estrogen through the action of the
aromatase, which synthesizes (aromatizes) testosterone into estrogen. However,
when concentrations of estrogen become too high and/or the normal ratio of
testosterone to estrogen decreases, the potential for the development of
undesirable conditions arises. This includes the development of the female
breast tissue (gynecomastia), increased body fat and water retention. Also,
research suggests that DHT and prostate tissue growth have a direct connection
to above normal estrogen elevations and reduced testosterone levels.
The ESTROGENEX Mechanism of Action
The ESTROGENEX proprietary formula was developed by combining naturally
occurring aromatase inhibitors and inhibitors of the action of SHBG. The primary
active ingredients in ESTROGENEX are Coumesterol and Chrysin.
ESTROGENEX does not exert its action through any direct hormonal or
prohormonal activity (androgenic or estrogenic).
Before ESTROGENEX , little success had been achieved using chrysin as an
effective aromatase inhibitor because chrysin is poorly absorbed in the
bloodstream. However, in addition to their own specific aromatase inhibiting and
estrogen blocking actions, the proprietary blend of other ingredients work in
synergy with chrysin to maintain a stable estrogen environment. We also
incorporated our proprietary delivery system called ESTROGENEX to avoid
competing with other hormones such as testosterone in the Aromatase Cytochrome
P450.
It is believed that ESTROGENEX exerts its effects through several
mechanisms of action, which can be classified into two groups:
- as an inhibitor of the aromatase enzyme responsible for the conversion
of testosterone to estrogen and an inhibitor of the action of SHBG, and
- as a blocker of selective anabolic estrogen receptors and/or inhibitor
of selective estrogen signaling.
Substances that are aromatase inhibitors block the action of the enzyme
aromatase that converts testosterone to estrogen. Substances that act as an
anti-estrogen are those that block the estrogen receptor. Thus, even though
there is estrogen circulating in the blood, the estrogen cannot exert its
effects because it is blocked from attaching to its estrogen receptor. The
dietary supplement ESTROGENEX is a multi-pathway agent that exerts its
influence by blocking various stages in the aromatase process and by inhibiting
SHBG's action; an activity not clearly addressed by any of the aromatase
inhibiting or anti-estrogen products. Further, it appears that use of
ESTROGENEX may result in long-term blocking of selective anabolic estrogen
receptors and/or inhibition of selective estrogen signaling (these anabolic
estrogens are those demonstrating the undesirable effects associated with breast
cancer and gynecomastia). This activity has not been addressed by any known
dietary supplements or pharmacological agents.
ESTROGENEX as an Elevator of Total Testosterone and Liberator of Free
Testosterone
As a powerful aromatase inhibitor, ESTROGENEX also possesses notable
testosterone stimulating properties. The aromatase inhibiting action reduces the
signal that estrogen sends to the brain to suppress endogenous testosterone
production (estrogen is a main feedback signal to control the release of
testosterone, thus increasing the testicular output of testosterone).
ESTROGENEX thus assists in resetting the body's level of its own natural
testosterone production by regulating the activity of the
hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the
body's production of testosterone to maintain target blood levels. Continued use
of ESTROGENEX results in not only a significant reduction in the
production of estrogen, but also a corresponding substantial increase in
endogenous testosterone.
Only ESTROGENEX addresses all possible channels to estrogen maintenance
and free testosterone elevation, which means optimal hormonal levels for muscle
building, fat loss and anti-aging support.
Suggested Use: Take 3 tablets daily.
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