NRx Mangosteen Extract Bulk Powder - 200g
Mangosteen Extract
10% Mangostin & 30% Polyphenols
Botanical source:
the whole fruit of Garcinia mangostana
L.
Chemical constituents:
The Mangosteen is an Asian tropical evergreen tree fruit that is often referred
to as the "Queen of Fruits". Mangosteen is considered to be the most abundant
source for Xanthones, which have shown potent antioxidant properties. Researches
have identified a total of 14 Xanthones from the hull, rind and the pulp of
Mangosteen fruits [1]. The deep-red rind of the fruit is considered to be the
major source of the nutritional benefits. Among the 14 known Xanthones,
alpha-Mangostin and gamma-Mangostin have been extensively studied. The sales of
Mangosteen juice are going up every year (e.g. 70% up in year 2005). This juice
has been taken primarily for efficacy rather than refreshment only. Even though
the Mangosteen Xanthones do not have good solubility in water, their suspension
is well accepted in the drink for their functional properties.
Pharmacology and clinicals: It is well-recognized that
consumption of fruits and vegetables can reduce the incidence of degenerative
diseases including cancer, heart disease, inflammation, arthritis, and immune
system decline etc. These protective effects are primarily resulted from the
presence of various antioxidants in fruits and vegetables. Mangosteen is
distinguished from many other fruits because of high antioxidant activities. The
pericarp (rind) of the Mangosteen fruit has been used in Southeast Asia as a
medicine for skin infection, wounds, and diarrhea for centuries [2]. Studies
have identified many compounds in Mangosteen, particularly Xanthons, which have
demonstrated potent antioxidant, anti-bacterial, and anti-fungal properties.
In-vitro studies also reported anti-cancer activity by Mangosteen extracts
[2-4]. No adverse side effects have been associated with Mangosteen whole fruit,
juice, or extracts [5].
Analytical specifications:
ProfileProvenTM Mangosteen is extracted from the
whole fruit of Mangosteen, including the rind, which contains more nutritious
Xanthones than the fruit pulp. Mangostin is controlled to be ≥10% by HPLC.
Meanwhile, Polyphenols are controlled to be ≥30% to ensure the overall
antioxidant potency of the extract.
SUPPLEMENT FACTS
Serving Size: 1 Scoop (1/4 tsp)
Servings Per Container: 240 |
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Amount Per Serving |
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%
Daily Value |
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Mangosteen
Extract
(10% Mangostin, 30% Polyphenols) |
830 mg |
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*Daily value not established. |
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Suggested Use: Take 500 - 1000 grams daily, mix with water
or your favorite beverage. Great for smoothies!
Shelf life and Storage: 2 years at room
temperature, in a cool and low humidity (< 55%) environment, away from direct
light.
Remarks:
Extracted by food-grade Ethanol and Distilled Water with extract ratio of
25:1; non-GMO; and ETO-free.
(*) Representative sample derived from drums of each lot, using the 'square root
of N + 1' method
(ENI.SOP.E502.7.2). Assay verified at an FDA Registered lab (ENI.SOP.H804.7.1).
(**) Verified by skip lot testing at an FDA Registered lab in accordance with
ENI testing protocol
(ENI.SOP.H804.7.2).
(***) In compliance with California Proposition 65 (< 0.5 μg/day) based on the
typical daily recommendation of 250 mg/day. Please note: Actual results may vary
± 5% to the specifications due to laboratory test variability.
References:
[1] Jung, H.A. et al.
Antioxidant xanthones from Pericarp of Garcinia mangostana (Mangosteen). J
Agric Food Chem 54 (2006), 2077–2082.
[2] Moongkarndi, P. et al. (2004). Antiproliferation, antioxidant and induction
of apoptosis by Garcinia mangosteen (mangosteen) on SKBR3 human breast cancer
cell line. J. Ethnopharmacol. 90, 161-166.
[3] Matsumoto, K. et al. (2003). Induction of apoptosis by xanthones from
mangosteen in human leukemia cell lines. J Nat Prod. 66(8), 1124-1127.
[4] HO, C.K. et al. (2002). Garcinone E, a xanthone derivative, has potent
cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med.
68(11), 975-979.
[5] Marcason, W. (2006). What are the facts and myths about Mangosteen? J Am
Diet Assoc. 106(6), 986.
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