NRx PomMAX™ Pomegranate Extract - 200g
PoMMax™ Pomegranate Extract
Full-Spectrum Pomegranate Fruit Extracts
75% Polyphenols, 15% Punicalagins & 2.5% Ellagic Acid
Botanical source:
the whole fruits of Punica granatum L.
Chemical constituents:
The fruit of Pomegranate is rich in potent polyphenolic antioxidants,
particularly ellagitannins: Punicalagins, Punicalin, and Gallic Acid, etc.
Punicalagins are unique polyphenols that are found most abundantly in
Pomegranate juice. They are therefore viewed as ideal markers for Pomegranate
derived products. Punicalagins are metabolized into Ellagic Acid after
consumption, and they are considered to be an ‘adoptic' precursor for Ellagic
Acid, which is only present at low levels (around 1%) as free Ellagic Acid in
Pomegranate fruit. Pomegranate extracts with high levels of Ellagic Acid
(20%-80%) are generally achieved by adding purified Ellagic Acid from other
sources to the extract.
Pharmacology and clinicals:
Pomegranate fractions with Ellagic Acid have been
extensively studied and noted for their strong anti-cancer and antioxidant
activities [1-4]. However, being insoluble in water, Ellagic Acid can only be
absorbed and utilized by human body after consumption of Punicalagins as one of
their metabolites [1]. It has also been suggested that the anti-cancer and
antioxidant benefits of Pomegranate reported by numerous studies derive from the
synergistic effects of the full spectrum of components found in the whole fruit,
rather than just the Ellagic Acid or other isolated pure chemicals alone [2-4].
Analytical specifications:
ProfileProvenTM Full-Spectrum Pomegranate fruit
extract is controlled to contain the key compounds present in a whole
Pomegranate fruit according to the ideal proportion set by nature to ensure the
100% benefit of the fruit. The content of Total Polyphenols (≥
75%) is tested by Folin-Ciocalteau method,
and the potencies of Punicalagins (≥ 15%) and Ellagic acid (≥ 2.5%) are
determined and HPLC analysis. Good Manufacturing Practice (GMP) and
standardization of active principals of product ensure that all batches meet
specifications.
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SUPPLEMENT FACTS |
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Amount Per Serving |
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Daily Value |
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PoMMax™
Pomegranate Extract
(75% Polyphenols / 15% Punicalagin / 2.5% Ellagic Acid) |
800 mg |
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*Daily value not established. |
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Suggested Use:
Take 800 - 1600mg daily,
mix with water or your favorite beverage.
Great for smoothies!
Shelf life and Storage:
2 years at room temperature, in a cool and low
humidity (< 55%) environment, away from direct light.
Remarks:
Extracted by Ethanol
(Food Grade) and Distilled Water with an extract ratio of 40:1; non-GMO;
ETO-free and non-irradiated.
(*) Representative sample derived from drums of
each lot, using the 'square root of N + 1' method (ENI.SOP.E502.7.2). Assay
verified at an FDA Registered lab (ENI.SOP.H804.7.1).
(**) Verified by skip lot testing at an FDA certified lab in accordance with ENI
testing protocol (ENI.SOP.H804.7.2).
(***) In compliance with California Proposition 65 (< 0.5 μg/day) based on the
typical daily recommendation of 200-400 mg.
Please note: Actual
results may vary ± 5% to the specifications due to laboratory test variability.
References:
[1] Seeram, N., et al. (2006). Pomegranate Juice Ellagitannin Metabolites
Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours. J.
Nutr. 136, 2481–2485.
[2] Rimonest Ltd. (2006). Short communication: Be aware of Pomegranates bearing
40% ellagic acid. Journal of Medicinal Food 9 (1), 119-122.
[3] Lansky E.P. et al (2005). Pomegranate (Punica granatum) pure chemical show
possible synergistic inhibition of human PC-3 prostate cancer cell invasion
across Matrigel. Invest New Drugs 23, 121–122.
[4] Aqqarwal, B., et al. (2006). Molecular targets of dietary agents for
prevention and therapy of cancer. Biochem Pharmacol, 71 (10), 397-421.
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