Try SleepMedic™ the new ground breaking
sleep-aid from TerraCeutics™.
Made with a synergistic blend of high-quality ingredients to help promote
healthy sleep.
Magnesium:
Insomnia is one of the central, or neurotic, symptoms of chronic magnesium
deficiency. (8) A number of parasomnias (night terrors; nocturnal verbal and
motor automatisms; restless legs syndrome) may be related to magnesium
deficiency. (9), (10)
Sleep in magnesium deficiency is usually agitated with frequent nocturnal
awakenings. Nocturnal instrument monitoring reveals major disorders of sleep
organization. The deficiency may be severe enough to be diagnosed on the basis
of clearly low blood magnesium levels. (10)
Conversely, a high magnesium, low aluminum diet has been found to be associated
with high-quality sleep time and few nighttime awakenings, (11) and magnesium
supplementation has been reported to reduce sleep latency and result in
uninterrupted sleep. (12)
References:
(8.) Durlach J et al. Magnesium and therapeutics. Magnes Res 7(3/4):313-28, 1994
(9.) Popoviciu L et al. Parasomnias (non-specific nocturnal episodic
manifestations) in patients with magnesium deficiency. Rom J Neurol Psychiatry
28(1):19-24, 1990
(10.) Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic
studies in restless legs syndrome caused by magnesium deficiency. Rom J Neurol
Psychiatry 31(1):55-61, 1993
(11.) Penland J. Effects of trace element nutrition on sleep patterns in adult
women. Fed Am Soc Exp Biol J 2:A434, 1988
(12.) Davis W, Ziady F. U. of Pretoria, S. Africa--presented at the Second
International Symposium on Magnesium, Montreal, 1976
Gaba:
GABA is the main inhibitory
neurotransmitter of the CNS. It is well established that activation of GABA(A)
receptors favors sleep. Three generations of hypnotics are based on these
GABA(A) receptor-mediated inhibitory processes. The first and second generation
of hypnotics (barbiturates and benzodiazepines respectively) decrease waking,
increase slow-wave sleep and enhance the intermediate stage situated between
slow-wave sleep and paradoxical sleep, at the expense of this last sleep stage.
The third generation of hypnotics (imidazopyridines and cyclopyrrolones) act
similarly on waking and slow-wave sleep but the slight decrease of paradoxical
sleep during the first hours does not result from an increase of the
intermediate stage. It has been shown that GABA(B) receptor antagonists increase
brain-activated behavioral states (waking and paradoxical sleep: dreaming
stage). Recently, a specific GABA(C) receptor antagonist was synthesized and
found by i.c.v. infusion to increase waking at the expense of slow-wave sleep
and paradoxical sleep. Since the sensitivity of GABA(C) receptors for GABA is
higher than that of GABA(A) and GABA(B) receptors, GABA(C) receptor agonists and
antagonists, when available for clinical practice, could open up a new era for
therapy of troubles such as insomnia, epilepsy and narcolepsy. They could
possibly act at lower doses, with fewer side effects than currently used drugs.
This paper reviews the influence of different kinds of molecules that affect
sleep and waking by acting on GABA receptors.
References:
Gottesmann
C.
-- GABA mechanisms and sleep.
Neuroscience
111(2):231-9, 2002
Valerian Root:
Valerian is one of the best gentle and
harmless herbal
sleeping remedies, it enhances the natural body process of slipping into sleep
and making the stresses of the day recede. Particularly for people who do not
need as much sleep as they once did, it also eases lying awake in bed, ensuring
that it becomes a restful and relaxing experience. It has been shown that
Valerian improves general sleep quality. Dream recall is relatively unaffected
by Valerian. It also promotes an easily and quicker descent into sleep. Taking
the herbs well before retiring, can reduce the noise induced disturbance of a
number of sleep stage patterns. Much research has centered on its effects upon
smooth muscle, demonstrating that it is a powerful and safe muscle relaxant.
Inositol:
Based on what is known about the role of
inositol in regulating serotonin levels, researchers have speculated that
inositol may assist people suffering with insomnia. Inositol is a fundamental
ingredient of cell membranes and is necessary for proper function of nerves,
brain, and muscles in the body. Inositol is essential for helping the cells in
the body communicate with one another, a process known as cell signaling.
Inositol is involved in the glucuronic acid and pentose phosphate pathways that
are responsible for products. Inositol exists as the fiber component phytic
acid, which has been investigated for its anti-cancer properties. Inositol is
involved in cellular responses to the actions of certain body hormones and
chemicals that are released from nerves, called neurotransmitters.
Passion Flower:
Passion flower has related analgesic,
sedative, sleep-inducing, and spasmolytic effects. The major pharmacological
effect of passion flower, first observed nearly a hundred years ago and
consistently reported ever since, is a sedative property. The analgesic property
of this herb was also observed, and doctors had success treating the
sleeplessness experienced by neurasthenic and hysteric patients, as well as that
caused by nervous exhaustion. Early investigators noticed that the herb worked
best when sleeplessness could be traced to an inflammation of the brain; passion
flower appeared to act as an analgesic and was free from side effects. Later in
this century, investigators discovered that the flavonoid fraction was more
effective. However, other tests showed that the most effective sedative activity
was obtained from a combination of both the flavonoids and the alkaloids.
Hops:
Hops are the flowers of Humulus lupulus,
a flowering vine native to North America, Asia, and Europe. Hops have been used
for centuries for their sedative qualities to help promote positive support for
sleep difficulty, occasional anxious feelings, restlessness, nervousness and
tension. The sedative action of hops is, in moderate amounts, mild and provides
relief from difficulties sleeping, without drowsiness the following morning.
Lemon Balm:
Lemon balm ( Melissa officinalis
), a member of the mint family, is considered a "calming" herb. It was used in
the Middle Ages to reduce stress and anxiety, promote sleep, improve appetite,
and ease pain and discomfort associated with digestion (including flatulence and
bloating as well as colic). Even before the Middle Ages, lemon balm was steeped
in wine to lift the spirits, help heal wounds, and treat venomous insect bites
and stings. Today, lemon balm is often combined with other calming, soothing
herbs, such as valerian, chamomile, and hops, to enhance the overall relaxing
effect.
L-Theanine:
L-theanine has shown the ability to
promote deep muscle relaxation and improve good quality sleep.
L-theanine is a relaxing amino acid
found in green tea available as a supplement. Clinical studies have shown
L-theanine to induce a sense of calm in patients with anxiety. At typical
dosages, L-theanine does not act as a sedative, but it does significantly
improve sleep quality.
Vitamin B6:
Vitamin B6, (pyridoxine) can
help prevent insomnia. Your body needs adequate B6 in order to produce serotonin
which is required for the sleep-triggering hormone called melatonin.
5-HTP:
While much less studied than
L-tryptophan, L-5-hydroxytryptophan, the immediate precursor to the
neurotransmitter serotonin, also appears to be effective in promoting sleep.
Moreover, it may be more effective than L-tryptophan in improving sleep patterns
as it increases the amount of time spent in REM sleep (during which dreaming
occurs), (15) while L-tryptophan decreases the time spent in this important
sleep stage. (16)
References:
(15.) Wyatt RJ et al. Effects of 5-hydroxytryptophan on the sleep of normal
human subjects. Electroencephalogr Clin Neurophysiol 30(6):505-9, 1971
(16.) Wyatt RJ. The serotonin-catecholamine-dream bicycle: A clinical study.
Biol Psychiatry 5:33-64, 1972
Melatonin:
Melatonin, produced naturally in our bodies, and is considered nature's miracle
sleep aid. Melatonin provides wonderful sleep without harmful side effects or
addiction from synthetic drugs. As we age, the ability to synthesize melatonin
decreases, allowing sleep patterns to change. Melatonin also relieves anxiety,
improves mood, and increases daytime energy. Melatonin is a naturally-occurring
hormone produced by the pineal gland that plays a role in the regulation of the
sleep-wake cycle. It is secreted by the pineal gland after your body senses the
fall of darkness at the end of each day. Melatonin keeps your body synchronized
with the rhythms of day and night and is a powerful antioxidant that supports
immune system function. As melatonin levels decline with age, supplementation is
necessary to provide optimal levels of this important hormone. Scientists
believe this reduction is the reason why older adults have more trouble sleeping
than younger people.
 |
SUPPLEMENT
FACTS
Serving Size: 2 Capsules
Servings Per Container: 30 |
|
|
|
|
|
Amount Per
Serving |
|
% Daily Value |
|
|
|
| Magnesium |
250 mg |
62% |
| Gaba |
150 mg |
* |
| Valerian root |
100 mg |
* |
|
Inositol |
100 mg |
* |
| Passion Flower |
100 mg |
* |
| Hops |
100 mg |
* |
| Lemon Balm |
100 mg |
* |
| L-Theanine |
50 mg |
* |
| Vitamin B6 |
50 mg |
2500% |
| 5-HTP |
25 mg |
* |
| Melatonin |
1 mg |
* |
|
|
| *Daily value
not established. |
|
|
|
|
|
Suggested Use: As a dietary supplement
take 1 - 2 capsules 1 hour before bedtime, or as directed by a health care
professional. Take consistently each day for best results.
Contains no: Sugar, starch, sodium, artificial colors or preservatives.
Warning: Do not use if tamper resistant seal is missing or broken. Seek
the advice of a health care professional before using. Consult your physician
prior to use if you are pregnant or nursing.
Storage: Keep this product in a cool dry place.
KEEP OUT OF REACH OF CHILDREN
QUALITY AND POTENCY GUARANTEED
